.alpha.-Hydroxy thioethers

US4808572A · kind A · utility

Assignee

• Ciba-Geigy · US

Inventors

• Andreas Beck · Glückstadt, DE
• Werner Breitenstein · Basel, CH
• Andreas von Sprecher · Oberwil, CH
• Robert W. Lang · Pratteln, CH
• Konrad Oertle · Therwil, CH

Key dates

• Filing date: Dec 1, 1986
• Grant date: Feb 28, 1989
• Expiry date: Dec 1, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel asymmetric thioethers of the formula ##STR1## in which the general symbols have the following meanings: a is an integer of from 1 to 7, PA0 R.sup.o represents hydrogen or C.sub.1-7 -alkanoyl, PA0 R.sup.1 represents C.sub.1-3 -alkyl which may be substituted at the terminal carbon atom by a free or acylated hydroxy group, by a halogen atom having an atomic number of at most 17, or by methoxy, or represents C.sub.1-3 -perfluoroalkyl, PA0 R.sup.2 represents an optionally unsaturated aliphatic radical having from 5 to 15 carbon atoms, PA0 A represents ethylene or alternatively, if R.sup.1 represents a halogenated radical and/or B represents phenylene or ethylene, a single bond or vinylene, PA0 B represents a single bond, ethynylene or phenylene, PA0 R.sup.3 represents hydroxy, C.sub.1-7 -alkoxy or an optionally substituted amino group, and PA0 --X-- represents a single bond, a methylene group of an optionally N-acylated primary aminomethylene group, and their salts are active as leucotriene antagonists since they eliminate the contractions of smooth muscles brought about by leucotrienes, and are therefore suitable for the treatment of allergic, especially asthmatic, conditions.