6-Alkylidene 10 .beta.-alkynylestrene derivatives and pharmaceutical methods for their use
US4808578A · kind A · utility
9Cited by
4References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1986 |
| Grant date | Feb 28, 1989 |
| Priority date | — |
| Expiry date | Dec 15, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to 6-substituted 10.beta.-alkynylestrene derivatives wherein the 6 substituent is amino, azido, halogen or an alkylidene group and to corresponding 6,7-dihalo analogs. The invention provides also a process for the preparation of the above compounds and pharmaceutical compositions containing same. The compounds of the invention are useful aromatase inhibitors and can be used, e.g., in the treatment of hormone-dependent tumors and prostatic hyperplasia.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.