Imidazolyl- indolylpropanones as 5-HT.sub.3 receptor antagonists
US4808581A · kind A · utility
26Cited by
2References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1988 |
| Grant date | Feb 28, 1989 |
| Priority date | — |
| Expiry date | Jan 22, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D403/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to compounds of formula (I): ##STR1## and physiologically acceptable salts or solvates thereof, wherein Im represents an imidazolyl group of formula: ##STR2## and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT.sub.3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.