Patent · US Expired

Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers

US4808700A · kind A · utility

48Cited by
13References
10Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 10, 1984
Grant dateFeb 28, 1989
Priority date—
Expiry dateAug 10, 2004

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10S530/812
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A conjugate, which is the reductive amination product of an immunogenic capsular polymer fragment, having a reducing end and derived from the capsular polymer of a bacterial pathogen, and the non-toxic polypeptide binding subunit of the heat-labile enterotoxin of Escherichia coli (LT-BNT). Also disclosed, are methods for the preparation of the conjugates and for the preparation of vaccines containing the conjugates which elicits an effective level of antibodies in humans. By administering an immunogenic amount of the conjugates, active immunization against systematic infection in young mammals caused by bacterial pathogens can be induced.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.