Phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides and their uses
US4808708A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1986 |
| Grant date | Feb 28, 1989 |
| Priority date | — |
| Expiry date | Oct 30, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Novel phosphorsulfide derivatives of deoxynucleosides or deoxynucleotides are provided, which have the general formula: ##STR1## wherein R.sup.1 is a hydroxy-protecting group; R.sup.2 is a phosphate-protecting group; R.sup.3 is an aryl group; B.sub.1 and B.sub.2 may be the same or different and each are a base residue which may have a protecting group; and n is zero or a positive integer, provided that if n is 2 or larger, the respective R.sup.2 may be the same or different. They are prepared by reacting a deoxynucleoside or deoxynucleotide with a 1,2,4-triazolylphosphine compound and are useful as intermediates for the preparation of oligodeoxy-nucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.