Patent · US Expired

Imidazoyl-substituted thiomethylpyridine derivatives, method of administration thereof and medicaments containing them

US4810715A · kind A · utility

16Cited by

1References

6Claims

0Family size

Assignee

Ludwig Heumann & Co. GmbH · DE

Inventors

Helmut Schickaneder · Eckental, DE
Heidrun Engler · Cadolzburg, DE
Istvan Szelenyi · Arnstorf, DE

Key dates

Filing date	Mar 16, 1987
Grant date	Mar 7, 1989
Priority date	—
Expiry date	Mar 16, 2007

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D487/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Thiomethylpyridine derivatives having bronchosecretolytic and mucolytic activity according to the formula: ##STR1## wherein R is a group attached in the 2-, 3- or 4-position of the pyridine ring which corresponds to the following general formula: EQU Q--S--CH.sub.2 -- (II) PA1 wherein Q is a substituted or unsubstituted aryl group or a 5- or 6-membered heterocyclic group which may optionally contain one or more substituents and/or which may be condensed with an optionally substituted phenyl group or with an optionally substituted heterocycle; PA1 R' is a lower alkyl group, a halogen atom or an aminoalkyl group; and PA1 n is 0 or an integer of from 1 to 4; and the therapeutically-acceptable acid addition salts thereof. The new compounds are distinguished by surprising activity compared with known compounds, such as "Ambroxol".

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.