Process for the preparation of stabilized isosorbide-5-mononitrate tablets, being also of sustained release, and formulations thus obtained
US4812316A · kind A · utility
12Cited by
3References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 1986 |
| Grant date | Mar 14, 1989 |
| Priority date | — |
| Expiry date | Oct 14, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to obtaining isosorbide-5-mononitrate tablets, being also of retard form, which are stable in time. Such embodiment is now possible after the discovery of the stabilizing activity of the with respect to the isosorbide-5-mononitrate with which it forms a solid solution. The use of PVP is essential so that the tablets can remain stable in time: the retard effect in turn can be obtained with the use of hydroxyalkylcelluloses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.