Transdermal laminated pharamaceutical compositions having prolonged effect and process for the preparation thereof
US4814174A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Sep 28, 1987 |
| Grant date | Mar 21, 1989 |
| Priority date | — |
| Expiry date | Sep 28, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/7084
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a transdermal laminated pharmaceutical composition (plaster) having prolonged effect, wherein one or more storing layer(s) comprising the active ingredient, an ethylene/vinyl acetate copolymer regulating layer and an adhesive layer are applied onto the carrier. The pharmaceutical composition is prepared by coupling a carrier comprising the active ingredient with a regulating layer consisting of an ethylene/vinyl acetate copolymer foil having a vinal acetate content of 2-40 molar %. The foil is previously irradiated in a thickness of 100-300 .mu.m with a high-energy irradiation in a dose of 1-15 Mrad--preferably with electrone radiation--and thereafter stretched at 80.degree.-90.degree. C. to a thickness of 2-200 .mu.m. The system comprising the carrier and the regulating layer is subsequently coupled with an adhesive layer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.