Substituted 1H-imidazoles
US4814343A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 2, 1987 |
| Grant date | Mar 21, 1989 |
| Priority date | — |
| Expiry date | Nov 2, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New substituted 1H-imidazoles and their salts, processes for the preparation thereof and pharmaceutical compositions. These compounds have the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.5 =hydrogen or C.sub.1 -C.sub.4 -alkyl; PA1 R.sub.4 =hydrogen, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy; PA1 Y.sub.1 =hydrogen and Y.sub.2 =OZ.sub.2 or the reverse; PA1 Z.sub.1 =Z.sub.2 =hydrogen or C.sub.1 -C.sub.4 -alkyl or Z.sub.1 and Z.sub.2 =--CH.sub.2 -- or --C(CH.sub.3).sub.2 --. These compounds are prepared either by reducing a corresponding imidazole compound having a hydroxyl or alkoxy group on the methyl bridge between the imidazole and phenyl rings, or by hydrolyzing a 4-[[2,2-dimethyl-4H-1,3-benzodioxin-6(or 8)-yl]methyl]-1H-imidazole, or yet by reducing an alkyl 3-[(1H-imidazol-4-yl)methyl]-2-hydroxybenzoate. These compounds have cardiac, cerebral and tissular anti-ischemic activities.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.