1-phenyl-2-aminocarbonylindole compounds, preparation thereof and pharmaceutical compositions containing them

US4814345A · kind A · utility

Assignee

• Kali-Chemie Pharma GmbH · DE

Inventors

• Heinrich-Wilhelm Ohlendorf · Hannover, DE
• Wilhelm Kaupmann · Hannover, DE
• Ulrich Kuhl · Gehrden, DE
• Gerd Buschmann · Velbert, DE
• Stephen J. Magda · Hannover, DE

Key dates

• Filing date: Nov 20, 1987
• Grant date: Mar 21, 1989
• Expiry date: Nov 20, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel 1-phenyl-2-aminocarbonylindole compounds are disclosed having the general formula I ##STR1## wherein R.sub.1 is an aliphatic or aromatic acyl group or an optionally substituted benzyl group; R.sub.2 is hydrogen or a lower alkyl radical; R.sub.3 is a hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R.sub.4 is hydrogen, a halogen, a lower alkyl radical, or a lower alkoxy radical; R.sub.5 has the significance given R.sub.3 ; R.sub.6 has the significance given for R.sub.4, or R.sub.6 is nitro or trifluoromethyl; R.sub.7 and R.sub.8 each represent hydrogen or a lower alkyl radical, or together with a nitrogen atom form a heterocyclic group; and Z signifies an alkylene chain optionally substituted by hydroxy or acyloxy. The compounds have pharmacological, in particular antiarrhythmic, properties.