Patent · US Expired

Method of producing a factor VIII (AHF) containing fraction

US4814435A · kind A · utility

21Cited by

16References

6Claims

0Family size

Assignee

Immuno Aktiengesellschaft fur chemisch-medizinische Produkte · AT

Inventors

Otto Schwarz · Waldshut-Tiengen, DE
Yendra Linnau · Wien, AT

Key dates

Filing date	Oct 15, 1987
Grant date	Mar 21, 1989
Priority date	—
Expiry date	Oct 15, 2007

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S530/83
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

There is disclosed a method of producing a Factor VIII (AHF) containing fraction having a specific activity of at least 2.5 units of Factor VIII/mg protein as well as a portion of immunoglobulin G (IgG) of 10 mg/1000 units of Factor VIII at the most. Its risk of transmission of viral or bacterial infections is to be avoided or largely reduced. The method consists in that undesired proteins are at first precipitated from a Factor VIII (AHF) containing plasma fraction in the presence of SPS. The purified Factor VIII containing solution is treated with suitable salts or salt mixtures in order to obtain a Factor VIII containing precipitate. This precipitate is dissolved, lyophilized and finally heat-treated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.