Quinoline compounds and compositions thereof
US4814454A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 22, 1987 |
| Grant date | Mar 21, 1989 |
| Priority date | — |
| Expiry date | Jun 22, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D215/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
p-Aminophenols are provided having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R.sup.1 and R.sup.2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R.sup.3 is H, lower alkyl, alkanoyl or aroyl; and R.sup.4 is H, lower alkyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when X is CH, m is 0 and R.sup.1 is H, and when R.sup.4 is H, R.sup.2 is other than alkoxy, H or hydroxy, and when R.sup.4 is benzoyl, R.sup.2 is other than H. These compounds together with the compounds defined in the above proviso are useful as inhibitors of leukotriene production and as such are useful as antiallergy, anti-inflammatory and anti-psoriatic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.