Method of inactivating reproductive filterable pathogens in fibrinogen and factor XIII compositions
US4816251A · kind A · utility
14Cited by
5References
13Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 13, 1985 |
| Grant date | Mar 28, 1989 |
| Priority date | — |
| Expiry date | Sep 13, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2/0023
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
There is disclosed a method of inactivating reproductive filterable pathogens in tissue adhesives containing fibrinogen and Factor XIII, with their biologic activity being largely preserved. In order to provide a tissue adhesive preparation of human or animal origin, which exhibits a high safety with respect to reproductive filterable pathogens and whose biologic activity is largely preserved, preparations having a minimum content of 100 units of Factor XIII/g of fibrinogen are heated in the dry state in the presence of an oxygen-free inert protective gas or under vacuum.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.