Human prealbumin and related methods and products
US4816388A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 30, 1985 |
| Grant date | Mar 28, 1989 |
| Priority date | — |
| Expiry date | Oct 30, 2005 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant human prealbumin and a method for producing such human prealbumin through recombinant DNA techniques including preparation and isolation of a cDNA sequence coding for human prealbumin, construction of a cloning vector and an expression vector containing said cDNA sequence, and expression of human prealbumin in a prokaryotic cell transformed by said expression vector are disclosed. The invention further relates to the use of human prealbumin cDNA in the diagnosis by hybridization methodologies of medical conditions with which variant forms of prealbumin are associated. Also disclosed is a method for diagnosing some Type I familial amyloid polyneuropathies by a restriction endonuclease assay with an enzyme which recognizes the nucleotide base sequence 5'-ATGCAT-3'.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.