Peptides and compositions

US4816441A · kind A · utility

Assignee

• Novo Industri A/S · DK

Inventors

• Jesper Zeuthen · Hellerup, DK
• Lars Thim · Copenhagen, DK
• Niels Peter Hundahl Moller · Munich, DE

Key dates

• Filing date: Nov 14, 1986
• Grant date: Mar 28, 1989
• Expiry date: Nov 14, 2006

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptides of the formula R.sup.1 -His-Asp-Glu-Ala-R wherein R.sup.1 is Ala-Gln, and R is a polypeptide residue with up to 50 amino acid residues, and wherein one, more or all of the amino acid residues in R.sup.1 and/or R independently may be omitted, can be used to augment cell mediated cytotoxicity and thereby to treat cancers and viral infections. These peptides may be prepared by proteolytic digestion of Staphylococcus aureus protein A, as well as by protein synthesis, recombinant DNA methods or any other methods known in the art.