Antibacterial 1,8-bridged 4-quinolonecarboxylic acids

US4816451A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Michael Schriewer · Odenthal, DE
• Klaus Grohe · Odenthal, DE
• Hermann Hagemann · Leverkusen, DE
• Hans-Joachim Zeiler · Velbert, DE
• Karl G. Metzger · Wuppertal, DE

Key dates

• Filing date: Jun 29, 1987
• Grant date: Mar 28, 1989
• Expiry date: Jun 29, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Antibacterially effective 1,8-bridged 4-quinolone-3-carboxylic acids and derivatives of the formula ##STR1## in which Y represents a carboxyl group, a nitrile group, an ester group --COOR.sup.7 or an acid amide group --CONR.sup.8 R.sup.9, PA1 X.sup.1 represents hydrogen, nitro, alkyl with 1-3 carbon atoms, or halogen, PA1 X.sup.5 represents hydrogen, halogen or alkyl, PA1 R.sup.10 and R.sup.11 complete an optionally substituted ring, and PA1 n is 0 or 1, and pharmaceutically usable hydrates, salts and esters thereof.