4,5-dihydro-3(2H)-pyridazinones and their pharmacological use

US4816454A · kind A · utility

Assignee

• Cassella Aktiengesellschaft · DE

Inventors

• Gerhard Zoller · Blankenloch, DE
• Rudi Beyerle · Frankfurt, DE
• Melitta Just · Langen, DE
• Helmut Bohn · Schöneck, DE
• Piero Martorana · Bad Homburg vor der Höhe, DE
• Rolf-Eberhard Nitz · Frankfurt am Main, DE

Key dates

• Filing date: Sep 12, 1985
• Grant date: Mar 28, 1989
• Expiry date: Sep 12, 2005

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted 4,5-dihydro-3(2H)-pyridazinones of the formula I ##STR1## wherein R, for example, denotes a radical of the formula ##STR2## R.sup.1 and R.sup.2, for example, denote hydrogen or methyl, R.sup.3, for example, denotes 2-methoxy-ethoxy, 3-pyridyl-methoxy, amino-carbonyl-methoxy, hydroxy-carbonyl-methoxy, methyl-thio, (2-methoxy-ethyl)-amino-carbonyl-methoxy, 3-pyridyl-methyl or 5-methyl-1,3,4-oxadiazol-2-yl and R.sup.4, for example, denotes hydrogen, have useful pharmacological properties and can therefore be used for the preparation of pharmacological products.