Heterocyclic compounds
US4816470A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 15, 1985 |
| Grant date | Mar 28, 1989 |
| Priority date | — |
| Expiry date | Nov 15, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/24
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Indole derivatives of the general formula (I) are disclosed: ##STR1## where R.sub.1 is H or an alkyl or alkenyl group, R.sub.2 is H, or an alkyl, alkenyl, aryl, aralkyl or cycloalkyl group; PA1 R.sub.3 is H or an alkyl group; PA1 R.sub.4 and R.sub.5 are independently H or an alkyl or propenyl group or together form an aralkylidene group; and PA1 Alk is an optionally substituted alkylene chain; and their physiologically acceptable salts and solutes. These compounds are potentially useful for the treatment of migraine and may be formulated as pharmaceutical compositions in conventional manner. Various methods for the production of the compounds are disclosed including a Fischer-indole cyclization process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.