Radioprotective agents having an amino-thioalkyl structure
US4816482A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 22, 1985 |
| Grant date | Mar 28, 1989 |
| Priority date | — |
| Expiry date | Feb 22, 2005 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/06026
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A pharmaceutical composition effective in the protection of normal tissues against radiation induced damage comprising administration a compound of the formula EQU R.sub.1 --CO--NR.sub.3 --/A/--S--R.sub.2 in which R.sub.1 is a radical corresponding to an amino acid R.sub.1 --COOH, /A/ is a C.sub.2 or C.sub.3 alkylene radical which can be substituted with a C.sub.1 to C.sub.3 alkyl radical, or with a hydroxy or hydroxycarbonyl radical or a --COR radical where R is an amino or --NH--CH.sub.2 --CO.sub.2 H radical, R.sub.2 is an acyl radical which protects the thiol group and which liberates the thiol group in vivo, R.sub.3 is a hydrogen, and also the salts of this compound with pharmaceutically acceptable acids.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.