Treatment of allergic conditions using indanyloxy-alkanol derivatives

US4816491A · kind A · utility

Assignee

• Frank M. Berger · US

Inventors

• Frank Berger · Leutenbach, DE
• Joseph I. DeGraw · Sunnyvale, US
• Howard L. Johnson · Joliet, US

Key dates

• Filing date: May 7, 1987
• Grant date: Mar 28, 1989
• Expiry date: May 7, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C51/367
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

p-Allyl or cycloalkyl phenoxy alkanols and esters are provided having the structure: ##STR1## in which: R.sub.1 is an alkyl group having from one to six carbon atoms, preferably tertiary, and still more preferably tertiary-butyl; or a bivalent cycloalkylene group condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; PA0 R.sub.2 is lower alkyl having from one to three carbon atoms or hydrogen; PA0 R.sub.3 is hydroxyl or an ester group selected from the group consisting of COOR.sub.4 and OOCR.sub.4 derived from unsubstituted and hydroxy-substituted monocarboxylic acids and COOR.sub.5 OOC and OOCR.sub.5 COO derived from unsubstituted and hydroxy-substituted dicarboxylic acids, the acids being selected from the group consisting of aliphatic acids, including carbamic acid, having from one to about twelve carbon atoms, cycloaliphatic acids having from three to about twelve carbon atoms; carbocyclic aromatic acids having from six to about twenty carbon atoms; and nitrogen heterocyclic aromatic acids having from five to about twelve carbon atoms, R.sub.4 being monovalent aliphatic, cycloaliphatic, aromatic, or nitrogen heterocyclic aromatic, and R.sub.5 being…