Method for producing hepatitis B virus proteins in yeast
US4816564A · kind A · utility
23Cited by
2References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 31, 1986 |
| Grant date | Mar 28, 1989 |
| Priority date | — |
| Expiry date | Jan 31, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S930/223
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The entire hepatitis B Virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The expressed protein aggregates into a particulate form which displays the major antigenic sites encoded by both domains, thereby highlighting the utility of yeast as a host for the expression of pre-S domains. This protein is useful in in vitro diagnostic systems and as a vaccine for the treatment and prevention of hepatitis B virus-induced diseases and/or infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.