Certain anti-inflammatory pyrazolo [4,3-b] pyridine 7-amines

US4818754A · kind A · utility

Assignee

• Beecham Group p.l.c. of Beecham House · GB

Inventors

• Robert W. Ward · Harlow, GB
• Roger E. Markwell · Harlow, GB
• Ian Hughes · Harlow, GB

Key dates

• Filing date: Apr 16, 1987
• Grant date: Apr 4, 1989
• Expiry date: Apr 16, 2007

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound of the formula (1) or a salt or solvate thereof: ##STR1## in which: R.sub.0 is hydrogen or C.sub.1-6 alkyl; PA0 R.sub.1 and R.sub.2 are both hydrogen; or PA0 R.sub.1 is hydrogen, C.sub.1-6 alkyl; and R.sub.2 is CN; CR.sub.5 R.sub.6 Y where R.sub.5 and R.sub.6 are independently selected from hydrogen and C.sub.1-4 alkyl and Y is selected from hydrogen, OR.sub.7 or SR.sub.7 where R.sub.7 is hydrogen, C.sub.1-4 alkyl or C.sub.2-4 alkanoyl, and NR.sub.8 R.sub.9 where R.sub.8 and R.sub.9 are independently hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkanoyl or together are C.sub.4-6 polymethylene; or COR.sub.10 is OH or C.sub.1-4 alkyl, or COR.sub.10 is a pharmaceutically acceptable ester or amide; or PA0 R.sub.2 is hydrogen, C.sub.1-6 alkyl, or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; and R.sub.1 is CN, CR.sub.5 R.sub.6 Y or COR.sub.10 as defined for R.sub.2 above; or PA0 R.sub.1 and R.sub.2 together form C.sub.3 -C.sub.6 polymethylene optionally substituted by C.sub.1 -C.sub.4 alkyl; PA0 R.sub.3 is --(CH.sub.2).sub.n CO.sub.2 R.sub.11, --(CH.sub.2).sub.n CONR.sub.12 R.sub.13,--(CH.sub.2).sub.n CN, --(CH.sub.2).su…