2-azolylmethyl-2-phenyl-4-[benzazol-2-yloxy-or-thio-methyl]-1,3 dioxolanes and salts thereof, pharmaceutical compositions containing them and their use

US4818758A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Klaus-Dieter Kampe · Bad Soden am Taunus, DE
• Wolfgang Raether
• Walter Dittmar · Hofheim, DE

Key dates

• Filing date: Mar 19, 1987
• Grant date: Apr 4, 1989
• Expiry date: Mar 19, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/66
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula I ##STR1## and the acid-addition salts thereof, where A=CH or N; Ar=naphthyl, thienyl or phenyl; Z=oxygen or sulfur; R.sup.1 =alkyl, F or Cl; g=0-2; L=0 or 1; m=0-4; p=0 or 1; X=O, S or N--R.sup.3 ; R.sup.2 =alkyl, alkoxy, halogen, SCH.sub.3, COC.sub.6 H.sub.5, CF.sub.3, COOCH.sub.3, COOC.sub.2 H.sub.5, or NO.sub.2 ; n=0-2; R.sup.2, under certain circumstances, is alternatively --CH.dbd.CH--CH.dbd.CH-- or phenoxy are described. Processes for the preparation thereof are also described. Compounds IIIa ##STR2## are valuable intermediates for the preparation of I. The compounds I serve as antimycotics.