Biologically active substance with hormonal properties, production process thereof and utilization of histones for medical purposes

US4818763A · kind A · utility

Assignee

• Volker Rusch · DE

Inventors

• Volker Rusch · Herborn, DE
• Robert Reichhart · Homburg, DE
• Michael Zeppezauer · Scheidt, DE
• Hans Jornvall · Mölndal, SE

Key dates

• Filing date: Sep 12, 1985
• Grant date: Apr 4, 1989
• Expiry date: Sep 12, 2005

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Biologically active substance with standardizable hormonal activity, containing in a physiological medium at least one histone, particularly at least one histone H2 or an active area of said histone with immune system immunostimulating and/or endocrinological properties. Utilization of histones and/or segments of histones for producing such a preparation for medical purposes. Said histones may be extracted from biological starting materials, for example calf thymus. Since H2A and H2B histones of oxen and humans are identical, ox histones may also be used for such a preparation for human medical purposes. The preparation according to the present invention may also contain only the variable evolution segments or part of at least one H2 histone. The invention is based on the fact that the biologically active area of an immunostimulating or endocrinologically active histone is located in the variable evolution histone segment. The preparation according to the present invention may be used in immunotherapy.