Assay for nucleic acid sequences, particularly genetic lesions, using interactive labels
US4820630A · kind A · utility
109Cited by
11References
25Claims
0Family size
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Key dates
| Filing date | Nov 23, 1984 |
| Grant date | Apr 11, 1989 |
| Priority date | — |
| Expiry date | Nov 23, 2004 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/80
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Lesions in genetic sequences, for example, the sickle cell anemia mutation in the beta globin gene, are detected by means of interactive labels in a nucleic acid hybridization assay. A signal is generated only if the labels are in physical proximity which is made dependent on whether a predetermined normal or abnormal sequence is present by exposure to appropriate conditions such as restriction enzyme digestion or stringent hybridization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.