Methylthioribose analogs, their preparation and use as medicinal agents and biocides

US4820692A · kind A · utility

Assignee

• State of Oregon, acting by and through the Oregon State Board of Higher Education, acting for and on behalf of the Oregon Health Sciences University and the University of Oregon · US

Inventors

• Michael K. Riscoe · Tualatin, US
• John H. Fitchen · Portland, US
• Adolph J. Ferro · Lake Oswego, US

Key dates

• Filing date: Jan 9, 1987
• Grant date: Apr 11, 1989
• Expiry date: Jan 9, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of the formula: ##STR1## wherein R is H, Cl, F, Br, I or R.sub.1 S--, in which R.sub.1 is C.sub.1 -C.sub.10 linear or branched chain alkyl or halogenated linear or branched chain alkyl, and PA0 wherein R.sub.2, R.sub.3 and R.sub.4 are the same or different and each is H-- or --OH, PA0 with the proviso that at least one of R.sub.2, R.sub.3 and R.sub.4 is hydroxy and the further proviso that when R.sub.2, R.sub.3 and R.sub.4 are all OH, R.sub.1 is other than methyl, are useful in inhibiting the growth of MTR kinase-dependent microorganisms and parasitic protazoans. The compounds wherein R is R.sub.1 S are novel, except those wherein R.sub.1 is methyl or isobutyl when R.sub.2, R.sub.3 and R.sub.4 are all OH.