Benzimidazole derivatives and pharmaceutical compositions containing them
US4820710A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 10, 1986 |
| Grant date | Apr 11, 1989 |
| Priority date | — |
| Expiry date | Sep 10, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Benzimidazole derivatives corresponding to the formula (1) ##STR1## in which X is CH or N, PA1 R.sub.1 is either a hydrogen atom, or a benzyl radical which can bear 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, (C.sub.1-4)alkyl, (C.sub.1-4)alkoxy, cyano, methylthio, methylsulphinyl and methylsulphonyl radicals, or a methyl radical bearing a heterocyclic substituent in which the heterocyclic system can be a pyridyl, thienyl or furyl radical and can bear one or more substituents, R.sub.2 is a hydrogen atom or a (C.sub.1-4)alkyl radical, R.sub.3 is a hydrogen atom or a hydroxy radical, and R.sub.4 is a hydrogen atom or a (C.sub.1-4)alkyl radical, where appropriate, in tautomeric form when R.sub.3 is OH. The compounds may be used in treating allergy and histamine-induced inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.