Preparation of a highly pure, substantially amorphous form of cefuroxime axetil
US4820833A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 4, 1986 |
| Grant date | Apr 11, 1989 |
| Priority date | — |
| Expiry date | Dec 4, 2006 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration. Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described. Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.