Process for .alpha.-C-alkylation of the 8-acyl group on mevinolin and analogs thereof
US4820850A · kind A · utility
51Cited by
4References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 10, 1987 |
| Grant date | Apr 11, 1989 |
| Priority date | — |
| Expiry date | Jul 10, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F7/1804
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for alkylating the alpha position of the 8-acyl side chain in mevinolin and analogs thereof is disclosed. The process proceeds with a single charge of base and alkyl halide to give products with a pharmaceutically acceptable purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.