Amphotericin B/cholesterol sulfate composition
US4822777A · kind A · utility
25Cited by
2References
3Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Feb 27, 1987 |
| Grant date | Apr 18, 1989 |
| Priority date | — |
| Expiry date | Feb 27, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 1:4. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 100-400 nm. The composition formed at a molar ratio of about 1:1 amphotericin B:cholesterol sulfate ahs stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.