Method of purifying bioactive substances by biospecific adsorption
US4824578A · kind A · utility
5Cited by
2References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 5, 1987 |
| Grant date | Apr 25, 1989 |
| Priority date | — |
| Expiry date | Feb 5, 2007 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S977/888
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
A ligand specific to a bioactive substance to be purified is fixed, through a connecting silane, to a mineral particulate carrier chosen from among SiO.sub.2, Al.sub.2 O.sub.3, ZrO.sub.2 and TiO.sub.2, the particles of the carrier being submicronic, non-porous and having a large specific surface. The carrier is contacted with an aqueous extract containing the bioactive substances, for the time required for the substance to become specifically fixed to the carrier. The carrier is then separated and the desired bioactive substance is isolated by desorption.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.