Antibody conjugates
US4824659A · kind A · utility
116Cited by
9References
17Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 7, 1985 |
| Grant date | Apr 25, 1989 |
| Priority date | — |
| Expiry date | Jun 7, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2123/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An antibody or antibody fragment is modified by chemical linkage to a synthetic poly(amide/urea/thiourea) which contains a plurality of boron atoms or other functional groups, conferring upon the resultant conjugate desirable properties as a diagnostic and/or therapeutic agent. In a preferred embodiment, boron-containing groups are conjugated to the antibody/fragment such that the resultant conjugate contains 50-2000 boron atoms, with about 96% Boron-10 isotope content, to produce conjugates useful for neutron-activated radiotherapy of tumors or pathological lesions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.