Cinnamoyl piperidines and thiomorpholine and cerebral protection compositions
US4824842A · kind A · utility
1Cited by
1References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 13, 1986 |
| Grant date | Apr 25, 1989 |
| Priority date | — |
| Expiry date | Feb 13, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D295/185
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the general formula ##STR1## wherein: X is halogen or trifluoromethyl; PA1 R.sub.1 is hydrogen, halogen or trifluoromethyl; PA1 R.sub.2 is hydrogen, methyl or hydroxymethyl; PA1 R.sub.3 is hydrogen or lower alkyl; and PA1 Y is methylene, methylene substituted with a lower alkyl or hydroxyl group, sulfinyl, sulfonyl, oxygen or sulfur, exhibit a cerebral protective effect and are applicable to the treatment of cerebral ischaemia and cerebral hypoxia. The compounds may be made by acylating a suitable piperidine or morpholine with the appropriate cinnamoyl chloride, and if necessary oxidizing the reaction product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.