Synthetic natriuretic peptides
US4824937A · kind A · utility
9Cited by
5References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 1987 |
| Grant date | Apr 25, 1989 |
| Priority date | — |
| Expiry date | May 14, 2007 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthetic natriuretic peptides (SNP) composed of 23 amino acid residues of which residues 2-23 have the natural L-configuration while the amino-terminal residue is derived from an unnatural amino acid having the D-configuration. The compounds possess diuretic, natriuretic, vasorelaxant, smooth muscle relaxant, hypotensive, and anti-hypertensive activities, and a process for their preparation is also disclosed, together with pharmaceutical preparations thereof and with their use in the practice of medicine. Salts of said synthetic natriuretic peptides with pharmaceutically acceptable acids are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.