3(2H)-pyridazinones and pharmaceutical compositions thereof
US4826845A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 29, 1986 |
| Grant date | May 2, 1989 |
| Priority date | — |
| Expiry date | Oct 29, 2006 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D405/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to novel 3(2H)-pyridazinone-derivatives of the general formula (I), pharmaceutical compositions containing them and process for their preparation. In the general formula (I) ##STR1## stands for an ethyl or propyl group substituted by a terminal halogen atom or a hydroxyl or NR.sup.1 R.sup.2 group, wherein PA2 R.sup.1 represents hydrogen atom or an unsubstituted or optionally substituted benzyl group; PA2 R.sup.2 represents hydrogen atom or an unsubstituted or optionally substituted benzo[1,4]dioxan-2-yl-methyl or -ethyl group or a (CH.sub.2).sub.n --R.sup.3 group, wherein PA3 n is 2 or 3; and PA3 R.sup.3 stands for an unsubstituted or optionally substituted phenoxy or phenylthio group; and PA1 X stands for a hydrogen or halogen atom or an unsubstituted or optionally substituted, saturated or unsaturated 5- or 6-membered heterocyclic group containing a nitrogen atom and optionally an additional heteroatom, e.g. an oxygen, sulfur or nitrogen atom, with the proviso that R is different from an ethyl or propyl group substituted terminally by a hydroxyl group or halogen atom when X represents a hydrogen or chlorine atom. The compounds of general formula (I) selectiv…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.