Novel ergolinyl compounds nitrogen-substituted in the 8-position, useful for treating dopamine deficiency

US4826852A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Gregor Haffer · Berlin, DE
• Gerhard Sauer · Berlin, DE
• Helmut Wachtel · Berlin, DE
• Herbert Schneider · Berlin, DE
• Ulrich Eder · Berlin, DE

Key dates

• Filing date: Jun 26, 1986
• Grant date: May 2, 1989
• Expiry date: Jun 26, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D457/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Ergolinyl compounds which are nitrogen-substituted in the 8-position and have Formula (I) ##STR1## and physiologically compatible salts thereof, wherein (a) R.sup.1 is hydrogen, the 8-substituent can be in the .alpha.- or .beta.-position and ##STR2## represents a single or a double bond, R.sup.2 is hydrogen, C.sub.1-4 -alkyl or C.sub.1-7 -acyl, PA0 R.sup.3 is hydrogen, chlorine or bromine, and PA0 R.sup.4 is C.sub.1-6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; or PA0 (b) R.sup.1 is ##STR3## and the 8-substituent can be in the .alpha.- or .beta.-position, ##STR4## represents a single or double bond, R.sup.2, R.sup.3 are as defined above, PA0 R.sup.4, is C.sub.1.varies.6 -alkyl, C.sub.3-6 -cycloalkyl-C.sub.1-3 -alkyl, C.sub.3-6 -alkenyl, or C.sub.3-6 -alkynyl; and PA0 R.sup.5 is hydrogen, C.sub.-10 -alkyl, C.sub.3-10 -alkenyl, or C.sub.3-10 -alkynyl, and PA0 R.sup.6 is C.sub.1-10 -alkyl, C.sub.3-10 -alkenyl, C.sub.3-10 -alkynyl, or aryl, or PA0 R.sup.5 and R.sup.6 together with the connecting N-atom form a 5- to 10-membered heterocyclic ring, preferably 5- or 6-membered, which optionally can contain further heteroatoms.