Bicyclic naphthalenic derivatives, a process for preparing the same and human or veterinary medicines and cosmetic compositions containing said derivatives

US4826969A · kind A · utility

Assignee

• Centre International de Recherches Dermatalogiques Galderma (C.I.R.D.) Galderma · FR

Inventors

• Jean Maignan · Gonesse, FR
• Gerard Lang · Saint-Gratien, FR
• Gerard Malle · Meaux, FR
• Serge Restle · Privas, FR
• Braham Shroot · Antibes, FR

Key dates

• Filing date: Oct 14, 1986
• Grant date: May 2, 1989
• Expiry date: Oct 14, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A bicyclic naphthalenic compound has the formula ##STR1## wherein A represents methylene or dimethylene, substituted or not by lower alkyl, PA0 R.sub.1, R.sub.2, R.sub.3 and R.sub.4 represent hydrogen or lower alkyl, or PA0 R.sub.1 and R.sub.3 taken together form a methylene or dimethylene bridge when A represents dimethylene, PA0 R' represents hydrogen, OH, alkoxy having 1-4 carbon atoms, acyloxy having 1-4 carbon atoms or amino, PA0 R" represents hydrogen or alkoxy having 1-4 carbon atoms, or PA0 r' and R" taken together form an oxo, methano or hydroxyimino group, PA0 R represents --CH.sub.2 OH or --COR.sub.5, PA0 R.sub.5 represents hydrogen, --OR.sub.6 or ##STR2## R.sub.6 represents hydrogen, alkyl having 1-20 carbon atoms, monohydroxyalkyl, polyhydroxyalkyl, aryl or aralkyl optionally substituted, the residue of a sugar or ##STR3## p is 1, 2 or 3, and r' and r", each independently, represent hydrogen, lower alkyl, monohydroxyalkyl optionally interrupted by a heteroatom, polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid, an aminoester or an aminated sugar, or r' and r" together form with the nitrogen atom to which they are attached, a heterocy…