Formation of hydroxy aryl carboxylic acids and esters
US4827845A · kind A · utility
3Cited by
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16Claims
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Key dates
| Filing date | Sep 23, 1987 |
| Grant date | May 9, 1989 |
| Priority date | — |
| Expiry date | Sep 23, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/83
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Hydroxy aryl carboxylic acids are formed by reacting a hydroxy aryl compound, such as phenol, with a ketone, such as acetone and carbon monoxide in the presence of a strong acid. The preferred embodiment is the one step formation of 2-methyl-2-(p-hydroxyphenyl) propionic acid from phenol, acetone and carbon monoxide in the presence of hydrofluoric acid. When this reaction is conducted in the presence of methanol the corresponding methyl ester is formed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.