Pulmonary surfactant

US4828844A · kind A · utility

Inventors

• Renate Rontgen-Odenthal · Freiburg im Breisgau, DE
• Manfred Durr · Bad Sobernheim, DE
• Ekkehard Harhausen · Cologne, DE

Key dates

• Filing date: Aug 4, 1983
• Grant date: May 9, 1989
• Expiry date: Aug 4, 2003

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P11/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A pulmonary surfactant for the treatment of dyspnea syndromes, containing dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) in a ratio of from 9:1 to 8:2 and a sugar, in the form of a redispersable powder, which is obtained by dissolving the phospholipids in glacial acetic acid, adding the sugar, and finally freeze-drying of the mixture. The lyophilisate is redispersed in a suitable buffer solution for application.