Polymer particles and latices thereof for the immobilization of biologically active substances

US4829101A · kind A · utility

Assignee

• Rohm Co., Ltd. · JP

Inventors

• Dieter Kraemer · Mainz, DE
• Werner Siol · Pfungstadt, DE
• Gerhard Markert · Ober-Ramstadt, DE
• Norbert Suetterlin
• Cornelia Feil · Langen (Hessen), DE

Key dates

• Filing date: Jul 20, 1987
• Grant date: May 9, 1989
• Expiry date: Jul 20, 2007

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S525/902
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Polymer particles dispersible to form a latex and latices of such polymer particles, said particles being adaptable to the fixing or bonding thereto of a biologically active substance and having a core-shell construction wherein the polymer material of the core determines the stability of the form of the latex particles and their redispersibility, and the material of the shell PA0 (1) is so hydrophilic that it would be completely or largely water soluble if it were not anchored to the core material and/or crosslinked, PA0 (2) contains functional groups which are suitable for the covalent fixation or bonding of biological active substances, and PA0 (3) in an anhydrous condition has a T.sub..lambda.max from 20.degree.-250.degree. C., depending on its composition, and methods for bonding a biologically active substance to such particles, for example to prepare a diagnostic reagent.