Cardiotonic benzimidazoles

US4831032A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Wolfgang von der Saal · Rosenheim, DE
• Alfred Mertens · Schriesheim, DE
• Herbert Berger
• Bernd Muller-Beckmann · Bamberg, DE
• Klaus Strein · Hemsbach, DE

Key dates

• Filing date: Jul 3, 1986
• Grant date: May 16, 1989
• Expiry date: Jul 3, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides benzimidazoles of the general formula: ##STR1## wherein R.sub.1, X, A, and R.sub.2 are as defined in the specification. The present invention also provides processes for the preparation of these new benzimidazoles and pharmaceutical compositions containing them, as well as intermediates for the preparation thereof. The new benzimidazoles are useful to treat heart or circulatory diseases which respond to a lowering of blood pressure, a positive inotropic action and/or an improvement in microcirculation.