Pyrrolizidine compounds, and their use as antiarrhythmic agents
US4831049A · kind A · utility
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3References
10Claims
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Key dates
| Filing date | Jul 3, 1985 |
| Grant date | May 16, 1989 |
| Priority date | — |
| Expiry date | Jul 3, 2005 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A novel pyrrolizidine compound of the formula ##STR1## wherein R.sup.1 is an alkyl group of 1 to 4 carbon atoms or a phenyl group; and R.sup.2 and R.sup.3 are such that at least one of them is an alkyl group of 1 to 4 carbon atoms and the other, if not alkyl, being a hydrogen atom is produced by reacting .DELTA..sup.4(8) -dehydropyrrolizidine with a substituted malonic acid and the thus formed 2-substituted-8-pyrrolizidineacetic acid with a substituted aniline. The products are subjected to optical resolution and are potentantiarrhythmic agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.