Extraction of alkaloids of Catharanthus roseus tissue
US4831133A · kind A · utility
3Cited by
2References
18Claims
0Family size
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Key dates
| Filing date | May 1, 1987 |
| Grant date | May 16, 1989 |
| Priority date | — |
| Expiry date | May 1, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Alkaloids present in Catharanthus roseus tissue are selectively concentrated by aqueous extraction of ground tissue followed by extraction with organic solvent e.g. ethyl acetate. The resultant concentrate is rich in catharanthine, vindoline and 3',4'-anhydrovinblastine (AVLB). Yield of AVLB is enhanced by addition to the aqueous extraction medium of acid, salt, or hydrogen peroxide and can be further enhanced through the addition of sodium borohydride.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.