Preparation of polypeptides having human .gamma.-interferon activity

US4832959A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Joachim Engels · Kronberg, DE
• Michael Leineweber · Frankfurt am Main, DE
• Eugen Uhlmann · Königstein, DE
• Wolfgang Ulmer · Munich, DE

Key dates

• Filing date: Mar 4, 1985
• Grant date: May 23, 1989
• Expiry date: Mar 4, 2005

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S930/142
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Partial sequences of human-.gamma.-interferon, comprising aminoacid sequences 5 to 127, 1 to 127 and 5 to 146, having biological activity. These partial sequences can be obtained by a genetic engineering process, for which purpose the appropriate DNA sequences are chemically synthesized. The DNA sequences are incorporated in hybrid plasmids, and the latter are introduced into host organisms and their expression is induced there. The biologically active polypeptides are suitable, as is human-.gamma.-interferon, for medicaments.