Antidepressant amines

US4833143A · kind A · utility

Assignee

• THE BOOTS COMPANY PLC · GB

Inventors

• Bernard John Armitage
• John R. Housley · Matlock, GB
• James E. Jeffery · Nottingham, GB
• David Johnston · Nottingham, GB

Key dates

• Filing date: Sep 28, 1983
• Grant date: May 23, 1989
• Expiry date: Sep 28, 2003

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of formula I ##STR1## in which R.sub.1 is a heterocyclic ring containing one or more heteroatoms selected from N, O and S; PA0 in which R.sub.2 is H, a straight or branched chain alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 3 to 6 carbon atoms, an alkynyl group containing 3 to 6 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms; PA0 in which R.sub.3, is H, a straight chain alkyl group containing 1 to 3 carbon atoms or a formyl group PA0 in which R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are H, halo, trifluoromethyl, hydroxy, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, phenyl or R.sub.4 and R.sub.5, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring; and their pharmaceutically acceptable salts have utility in the treatment of depression. Pharmaceutical compositions and processes for the preparation of compounds of formula I are disclosed.