Tertiary hydroxyalkylxanthines, medicaments containing them and their use

US4833146A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Ulrich Gebert · Königstein, DE
• Ismahan Okyayuz-Baklouti · Wiesbaden, DE
• Werner Thorwart · Hochheim, DE

Key dates

• Filing date: Mar 16, 1987
• Grant date: May 23, 1989
• Expiry date: Mar 16, 2007

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tertiary hydroxyalkylxanthines having the general formula (I), characterized by the fact that at least one of the residues R.sup.1 and R.sup.3 represents a tertiary hydroxyalkyl group of formula (Ia) in which R.sup.4 represents an alkyl group having up to 3 carbon atoms and n a whole number from 2 to 5; the other residue which may remain R.sup.1 or R.sup.3 is a hydrogen atom or an aliphatic hydrocarbon residue R.sup.5 having up to 6 carbon atoms, in which the carbon chain may be separated by a maximum of two oxygen atoms or be substituted by an oxo group or two hydroxy groups at the most, and R.sup.2 represents an alkyl group with 1 to 4 carbon atoms. Also described is a process for manufacturing these compounds, which are suitable for the manufacture of medicines, in particular for use in the prevention and/or treatment of peripheral and/or cerebral irrigation disorders. ##STR1##