3-(.omega.-(3,5,-di-t-butyl-4-hydroxyphenyl)-alkanoyl)pyrroles, and anti-inflammatory uses thereof

US4833155A · kind A · utility

Assignee

• Syntex (U.S.A.) LLC · US

Inventors

• Joseph M. Muchowski · Mexico City, MX
• Robert Greenhouse · Newark, US
• John M. Young · Palm Harbor, US
• D. V. Krishna Murthy · Cupertino, US

Key dates

• Filing date: Nov 25, 1986
• Grant date: May 23, 1989
• Expiry date: Nov 25, 2006

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D207/36
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

3-[.omega.-(3,5-Di-t-butyl-4-hydroxyphenyl)alkanoyl]-pyrroles and their de-oxy analogs, for example, 3-(3,5-di-t-butyl-4-hydroxybenzyl)pyrrole, 2-chloro-4-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole, 3-(3,5-di-t-butyl-4-hydroxybenzoyl)pyrrole and 3-[2-(3,5-di-t-butyl-4-hydroxyphenyl)-1-oxoethyl]pyrrole, have high pharmacological potency as anti-inflammatory, analgesic and antipyretic agents.