Stereoselective reduction of the keto group at 7-position of a bile keto acid
US4834919A · kind A · utility
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8Claims
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Key dates
| Filing date | Jan 6, 1987 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Jan 6, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J9/005
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The keto group at the 7-position of a bile keto acid is stereoselectively reduced to a beta-hydroxy group with hydrogen in the presence of nickel, a base (the quantity of which is at least 0.3 mole for each mole of keto acid), and an alcohol having from 3 to 10 C atoms, selected from the group consisting of secondary alcohols, tertiary alcohols and beta-branched alcohols.
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