Apparatus for blot screening numerous, small volume, antibody solutions
US4834946A · kind A · utility
Inventor
Key dates
| Filing date | Feb 5, 1987 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Feb 5, 2007 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B60/14
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A cover plate, having a lower, flat surface containing an array of numerous, parallel, closely spaced apart, downwardly opening channels, is releasably clamped upon a flat support plate surface. The channels each have inlet and outlet holes communicating with the upper surface of the cover plate. A paper-like, resilient cushion sheet is clamped between the plate surfaces and a paper-like membrane, carrying a pattern of antigen-like material, is arranged between the sheet and the cover plate channeled surface. The channels are very narrow, shallow and many times longer than their widths and are closed by the stripe-like portions of the membrane which overlie the channels. The cushion sheet is compressed between adjacent channels and bulges upwardly at each of the channels to thereby bulge the membrane stripe-like portions into dome-shaped cross-sections extending into the channels. This reduces the volumes of the channels and increases the surface areas of the membrane stripe-like portions that are exposed within the channels. Numerous drop-size samples of antibody-type solutions are inserted into the channels through channel inlet holes, that extend through the cover plate, for rea…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.