Monoclonal antibodies to pseudomonas aeruginosa flagella
US4834976A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 24, 1986 |
| Grant date | May 30, 1989 |
| Priority date | — |
| Expiry date | Dec 24, 2006 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/811
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Cell lines have been produced that secrete monoclonal antibodies capable of binding to the flagellar proteins of selected Pseudomonas aeruginosa strains. Some of these antibodies have been found to be protective against lethal challenges of P. aeruginosa. Pharmaceutical compositions containing these antibodies, which can be in combination with other monoclonal antibodies, blood plasma fractions and antimicrobial agents, and the prophylactic and therapeutic use of such compositions in the management of infections, are included. Prior to filing this application, the continuous transformed cell lines PaF4 IVE8, FA6 IIG5, 20H11, and 21B8, described herein, were deposited in the America Type Culture Collection and given the designations HB9129, HB9130, CRL 9300, and CRL 9301, respectively.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.